Long interspersed nuclear element-1 (LINE-1 or L1) is the only active, self-copying genetic element in the human ...

The INO80 chromatin remodelling complex has various roles in genome maintenance, acting via nucleosome sliding and H2A.Z removal. Here, it is shown to also facilitate the bypass of DNA lesions during ...

They observe how the mobile DNA LINE-1 copies its sequence in human cells, revealing the precise mechanism of the ORF2p gene.

Researchers used cryo-EM to study how the HIV enzyme integrase arranges in 3D to slip its DNA into the host genome and pack ...

The complex appears to reel in the DNA around the mismatch as well, marking and protecting the DNA region until repair can occur. "Due to the mobility of these proteins, current thinking envisioned ...

An international research team has determined the first high-resolution structures of the herpes simplex virus origin-binding ...

Breakthrough cryo-EM structures expose multiple drug targets in an essential HSV-1 replication protein.An international ...