Scientists have zeroed in on a critical weak spot behind a rare but devastating brain autoimmune disorder often known as ...

Figure 1: Co-agonist stimulation induces dynamin-dependent NMDA receptor internalization. Figure 2: Glycine site stimulation initiates a progressive decline in NMDA receptor-mediated currents. Figure ...

Glutamate is the main excitatory neurotransmitter in the mammalian CNS and mediates neurotransmission across most excitatory synapses. Three classes of glutamate-gated ion channels (AMPA, kainate and ...

The difference between mental health and mental illness can turn on changes in brain cells and their connections that are almost incomprehensibly tiny, at least in physical terms. This irony is ...

NRx Pharmaceuticals, Inc. (NASDAQ: NRXP), a clinical-stage biopharmaceutical company developing therapeutics based on its ...

Researchers review the future of schizophrenia treatment, highlighting TAAR1 agonists, NMDA enhancers, and the gut-brain axis ...

Structural biologists at Cold Spring Harbor Laboratory (CSHL) and collaborators at Emory University have obtained important scientific results likely to advance efforts to develop new drugs targeting ...

Gainesville, FL - Temporal summation of repeated pain stimuli, also known as "windup" pain, is mediated by N-methyl-D-aspartate (NMDA) receptors, and this pathway has long been suspected of ...

A new study suggests a potential molecular strategy for treating fragile X syndrome, an inherited neurodevelopmental disorder that causes autism spectrum disorder and intellectual disability. This ...

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...

Cold Spring Harbor, NY - The difference between mental health and mental illness can turn on changes in brain cells and their connections that are almost incomprehensibly tiny, at least in physical ...