Phosphorylation | Definition, Function & Mechanism

🌾🌾Dr.Agrarian🌾🌾 on Instagram: "p53 is one of the most important tumor-suppressor proteins in eukaryotic cells and is often called the “guardian of the genome.” 1. Basic information Gene name: TP53 Location in humans: Chromosome 17p13.1 Protein type: Sequence-specific transcription factor Normal half-life: Very short (~20 min), tightly regulated. Mutations: Found in ~50% of human cancers, making it the most frequently mutated tumor-suppressor gene. 2. Structural domains of p53 protein p53 is